Microbial Diseases, Royal Free Campus,University College London, London, NW3 2PF
Dedicated to improving oral and gastrointestinal health
SARCOPENIA
Background
Sarcopenia is a condition that causes slow, long-term decay of the muscles used in movement. This results in weakness, reduced capacity for physical activity and increased risk of falls- greatly impacting one’s quality of life, as well as health and safety. Whilst sarcopenia has generally been linked to aging and the elderly population, new research suggests it may also occur in individuals of all age groups suffering from inflammation-associated disorders, such as inflammatory bowel disease and also cancer patients.
Click on image above to see Saskia Inniss - 3 minute thesis presentation on the impact of sarcopenia on Ustekinumab therapy in Crohn's disease
Research
Current research is focused on determining how individuals with inflammatory bowel disease respond to conventional therapy and how sarcopenia changes the outcome. We have an ongoing clinical observational study (IRAS 277231) across both University College Hospital and The Royal Free Hospital.
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We are also running a questionnaire to determine the extent of peoples knowledge of sarcopenia and its impact on individuals with inflammatory bowel disease. If you would like to partcipate see the section below.
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Publications
Two-year real-world outcome data from a single tertiary centre shows reduced ustekinumab persistence in a non-bio-naïve Crohn’s disease cohort with penetrating disease, ostomies and sarcopenia.
S Inniss ,KC Fragkos et al FZ Rahman
Therapeutic Advances in Chronic Disease 2023;14
https://doi.org/10.1177/20406223231189072
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P508 Sarcopenia is associated with increased rates of infectious post-operative complications in Crohn’s disease patients
K Simpson, S Inniss, KC Fragkos, CPJ Wood, A Smith, FZ Rahman
Journal of Crohn's and Colitis, Volume 17, Issue Supplement_1, February 2023, Pages i639–i640,
https://doi.org/10.1093/ecco-jcc/jjac190.0638
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Interested in getting involved in our sarcopenia research?
We are currently conducting an anonymised questionnaire to determine the current perception of the impact of sarcopenia on individuals with inflammatory bowel disease.
We are keen to have the views of people with and without inflammatory bowel disease
To Access the questionnaire
More information on sarcopenia and malnutrition can be found via clicking on the image below.
